Opportunity Information: Apply for PA 19 091
The NIH Research Project Grant (Parent R01) opportunity titled "Basic Experimental Studies with Humans Required" (Funding Opportunity Number PA 19 091) is a discretionary NIH grant mechanism designed to support a clearly defined, investigator-driven research project. It uses the standard R01 structure, meaning it is intended for a discrete, specific, and circumscribed line of work that fits the expertise and scientific direction of the proposing investigator(s). The focus is on basic science questions, but in a very particular setting: studies that involve human participants in a way that meets NIH's definition of a clinical trial, while still being considered basic research in purpose and intent.
This announcement is meant for prospective basic experimental studies in humans, as referenced in NIH guidance (NOT-OD-18-212). In practical terms, it fits research where investigators actively assign people to one or more experimental conditions, such as manipulating an independent variable (for example, changing a stimulus, task condition, environmental exposure, behavioral prompt, or other experimentally controlled factor) and then measuring biomedical or behavioral outcomes directly in humans. The defining feature is that the study is designed to understand fundamental mechanisms or phenomena, rather than to test a specific product, therapy, service, or applied intervention intended for real-world implementation. If a project is aimed at developing or evaluating a specific application (for instance, a treatment protocol, an implementation strategy, or a product-oriented outcome), NIH expects applicants to use a different pathway, specifically a "Clinical Trials Required" funding opportunity that matches that applied intent.
Even though the work is basic science, the studies covered here still fall under NIH's clinical trial framework because they involve prospective assignment and outcome assessment in human participants. As a result, applicants should expect the kinds of planning and compliance elements typically associated with NIH clinical trials, such as clear protocol-driven methods, participant protections, and appropriate oversight, while keeping the scientific framing rooted in basic research goals. Another key point is that proposals must align with the programmatic interests of at least one participating NIH Institute or Center (IC). In other words, the scientific topic needs to fit within an IC's mission area, since funding decisions and relevance are tied closely to those missions.
Eligibility is broad and includes a wide range of organizations and government entities. Eligible applicants include state, county, city or township, and special district governments, as well as independent school districts. Academic eligibility spans public/state-controlled and private institutions of higher education. Tribal eligibility includes federally recognized Native American tribal governments and other Native American tribal organizations, as well as Indian/Native American tribal governments that are not federally recognized in certain cases described by NIH. Nonprofits are eligible whether or not they hold 501(c)(3) status, provided they are not institutions of higher education in that classification. For-profit organizations (other than small businesses) and small businesses are also listed as eligible. The announcement also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations), reflecting NIH's openness to a wide applicant pool when the science and mission fit are strong.
The opportunity is administered by the National Institutes of Health, with associated CFDA numbers spanning multiple NIH programs (including 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.361, 93.853, 93.866, and 93.879). The source record lists an original closing date of 2020-05-24 and a creation date of 2018-11-28, and it does not specify an award ceiling or expected number of awards in the provided data. Overall, the core purpose of this FOA is to give investigators a standard R01 route for rigorous, experimentally controlled human research that is fundamentally basic science in objective, but structured in a way that meets NIH clinical trial criteria because it prospectively assigns participants and measures outcomes.Apply for PA 19 091
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.361, 93.853, 93.866, 93.879.
- This funding opportunity was created on 2018-11-28.
- Applicants must submit their applications by 2020-05-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is the NIH Research Project Grant (Parent R01) funding opportunity titled "Basic Experimental Studies with Humans Required" (Funding Opportunity Number PA 19 091). It supports a clearly defined, investigator-driven research project using the standard R01 structure.
What does "Parent R01" mean in this context?
It means the opportunity uses NIH's standard R01 framework for a discrete, specific, and circumscribed line of research. The project should align with the proposing investigator(s) expertise and scientific direction, rather than being a narrowly specified project design dictated by the announcement.
What kinds of studies are this FOA designed to support?
This FOA is intended for basic experimental studies in humans. These are prospective studies where investigators actively assign human participants to one or more experimental conditions and measure biomedical or behavioral outcomes, while aiming to understand fundamental mechanisms or phenomena (basic science).
Why does this FOA say "clinical trial" if it is basic research?
Even when the scientific objective is basic research, the studies covered here meet NIH's definition of a clinical trial because they involve prospective assignment to conditions and outcome assessment in human participants. The clinical trial designation comes from the study design (prospective assignment and outcomes), not from whether the goal is applied or basic.
What is meant by "Basic Experimental Studies with Humans"?
In practical terms, it refers to studies where researchers manipulate an independent variable (such as a stimulus, task condition, environmental exposure, behavioral prompt, or another experimentally controlled factor) and directly measure the resulting biomedical or behavioral outcomes in humans, with the purpose of understanding fundamental processes.
What is the main scientific focus: basic science or applied intervention testing?
The focus is basic science questions. The defining feature is that the study is designed to understand fundamental mechanisms or phenomena, not to test a specific product, therapy, service, or applied intervention intended for real-world implementation.
If my project tests a treatment or product, is this the right FOA?
Based on the description provided, no. If a project is aimed at developing or evaluating a specific application (for example, a treatment protocol, an implementation strategy, or a product-oriented outcome), NIH expects applicants to use a different pathway, specifically a "Clinical Trials Required" funding opportunity that matches that applied intent.
What does "Required" mean in the title ("Basic Experimental Studies with Humans Required")?
It indicates that the type of research expected under this opportunity involves basic experimental studies in humans that meet NIH's clinical trial definition (prospective assignment and outcome assessment). The FOA is positioned specifically for that category of research.
Do applicants need to follow clinical trial planning and oversight practices?
Yes. Even though the work is basic science in intent, the studies fall under NIH's clinical trial framework. Applicants should expect protocol-driven methods, participant protections, and appropriate oversight consistent with clinical trial expectations, while keeping the scientific framing rooted in basic research goals.
What are examples of acceptable experimental manipulations in human participants?
The opportunity description gives examples such as changing a stimulus, task condition, environmental exposure, behavioral prompt, or other experimentally controlled factors, then measuring biomedical or behavioral outcomes directly in humans.
Does my project have to align with an NIH Institute or Center (IC)?
Yes. Proposals must align with the programmatic interests of at least one participating NIH Institute or Center. In practice, the scientific topic needs to fit within an IC's mission area because funding decisions and relevance are closely tied to those missions.
Who can apply for this grant?
Eligibility is broad. Eligible applicants include various government entities (state, county, city or township, special district governments, and independent school districts), higher education institutions (public/state-controlled and private), tribal governments and tribal organizations (including certain non-federally recognized tribal governments in cases described by NIH), nonprofit organizations (with or without 501(c)(3) status, as described), for-profit organizations (other than small businesses), and small businesses.
Are minority-serving institutions and community-based organizations eligible?
Yes. The announcement explicitly highlights eligibility for categories such as HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs, as well as faith-based or community-based organizations (among other eligible applicant types).
Are federal agencies eligible to apply?
Yes. The announcement lists eligible federal agencies among the eligible applicant categories.
Can U.S. territories or possessions apply?
Yes. U.S. territories or possessions are included among eligible applicant categories.
Are foreign (non-U.S.) organizations eligible?
Yes. The announcement indicates that non-U.S. entities (foreign organizations) are eligible, reflecting NIH openness to a wide applicant pool when the science and mission fit are strong.
Who administers this opportunity?
The opportunity is administered by the National Institutes of Health (NIH).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number provided is PA 19 091.
Is this opportunity discretionary?
Yes. It is described as a discretionary NIH grant mechanism supporting investigator-driven research projects under the R01 structure.
What CFDA numbers are associated with this opportunity?
The opportunity lists multiple associated CFDA numbers: 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.361, 93.853, 93.866, and 93.879.
What are the key dates listed for this opportunity?
The source record lists a creation date of 2018-11-28 and an original closing date of 2020-05-24.
Is there an award ceiling or an expected number of awards stated?
No. In the provided information, the record does not specify an award ceiling or the expected number of awards.
How should applicants frame their project to fit this FOA?
Based on the description provided, applicants should frame their project as a rigorous, experimentally controlled study in humans that is fundamentally basic science in objective, while also addressing clinical trial-related expectations (prospective assignment, outcome assessment, protocol-driven approach, and participant protections). The topic should also clearly align with the mission of at least one participating NIH Institute or Center.
What NIH guidance is referenced for the type of research covered here?
The announcement references NIH guidance on basic experimental studies in humans: NOT-OD-18-212.
What is the core purpose of this FOA in one sentence?
Its core purpose is to provide a standard R01 route for rigorous, experimentally controlled human research that is basic science in intent, but that meets NIH clinical trial criteria because it prospectively assigns participants and measures outcomes.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 19 091) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 19 092 Funding Number: PA 19 092 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 088 Funding Number: PA 19 088 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed) Apply for PAR 19 098 Funding Number: PAR 19 098 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required) Apply for PA 19 121 Funding Number: PA 19 121 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed) Apply for PA 19 122 Funding Number: PA 19 122 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) Apply for PA 19 131 Funding Number: PA 19 131 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) Apply for PA 19 132 Funding Number: PA 19 132 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| U.S.-China Program for Biomedical Collaborative Research (R01 Clinical Trial Optional) Apply for RFA CA 19 009 Funding Number: RFA CA 19 009 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $150,000 |
| Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed) Apply for PAR 19 158 Funding Number: PAR 19 158 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Summer Research Education Experience Program (Clinical Trials Not Allowed R25) Apply for PAR 19 164 Funding Number: PAR 19 164 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $100,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 19 187 Funding Number: PA 19 187 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Summer Research Education Experience Program (R25 Clinical Trial Not Allowed) Apply for PAR 19 197 Funding Number: PAR 19 197 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $100,000 |
| Building Interdisciplinary Research Careers in Women's Health (BIRCWH); K12 Clinical Trial Optional Apply for RFA OD 19 020 Funding Number: RFA OD 19 020 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $600,000 |
| Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R21 Clinical Trial Optional) Apply for PAR 19 252 Funding Number: PAR 19 252 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Populations (R01 Clinical Trial Optional) Apply for PAR 19 250 Funding Number: PAR 19 250 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Optional) Apply for PAR 19 251 Funding Number: PAR 19 251 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R21 Clinical Trial Optional) Apply for PAR 19 275 Funding Number: PAR 19 275 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 19 011 Funding Number: RFA ES 19 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| The Intersection of Sex and Gender Influences on Health and Disease (R01 Clinical Trial Optional) Apply for RFA OD 19 029 Funding Number: RFA OD 19 029 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed) Apply for PA 20 047 Funding Number: PA 20 047 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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