Opportunity Information: Apply for RFA HL 19 006
The grant opportunity "Management of Asthma in Primary Care - Bioinformatics Center (U24 - Clinical Trial Required - Infrastructure)" (Funding Opportunity Number RFA HL 19 006) is a National Institutes of Health (NIH) cooperative agreement designed to strengthen evidence on how asthma is managed in real-world primary care. The central aim is to identify what primary healthcare providers are currently doing to manage asthma patients and then prospectively evaluate how effective those approaches are. Rather than focusing on a single medication or a narrow intervention, the project is structured to examine existing care practices and use those findings to define "best practices" that can guide future clinical decision-making in primary care settings.
A key feature of this initiative is its reliance on electronic health record (EHR) systems as the foundation for both generating and testing care paradigms. In practical terms, applicants are expected to leverage EHR data to understand patterns of asthma care, measure outcomes, and support the design and execution of trials or prospective evaluations that compare different management approaches. Because it is labeled "Clinical Trial Required," the expectation is that the work will go beyond retrospective analyses and will include prospective testing of management strategies in a manner consistent with NIH clinical trial definitions. The overall intent is to produce actionable, practice-relevant evidence that can be integrated into primary care workflows, potentially improving consistency, quality, and outcomes for asthma patients.
This FOA funds a Bioinformatics Center under the U24 activity code, which typically supports shared resources and infrastructure rather than a conventional hypothesis-driven research project alone. Within the broader program structure, the Bioinformatics Center is responsible for the data and analytics side of the study. That includes building and maintaining the analytical infrastructure, handling complex EHR-derived datasets, supporting data harmonization and quality control, developing analytic plans, and carrying out statistical and informatics analyses needed to evaluate asthma management paradigms. The Bioinformatics Center is expected to work closely with a separately funded Clinical Center, which takes primary responsibility for study management, data collection operations, and the conduct of clinical trials. The cooperative agreement mechanism also signals substantial involvement from NIH program staff, with an emphasis on teamwork, coordination, and meeting program-wide milestones.
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those categories as listed); for-profit organizations other than small businesses; small businesses; and additional eligible entities as allowed by NIH policy. The FOA also highlights categories of "other eligible applicants" such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIS institutions, faith-based or community-based organizations, Hispanic-serving institutions, HBCUs, tribally controlled colleges and universities, regional organizations, and U.S. territories or possessions, reinforcing an interest in broad participation across diverse communities and care settings.
Foreign participation is explicitly limited. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible. In addition, foreign components as defined by the NIH Grants Policy Statement are not allowed, meaning the project must be carried out entirely within allowable U.S.-based organizational structures and locations.
From an administrative standpoint, the opportunity is categorized as discretionary funding, uses the cooperative agreement funding instrument, and falls under the health activity category with CFDA number 93.838. The original closing date listed is October 31, 2018, and the FOA record shows a creation date of August 2, 2018. While an award ceiling and expected number of awards are not specified in the provided summary fields, the overall structure indicates a coordinated, multi-component program in which the Bioinformatics Center plays a central role in enabling rigorous EHR-driven evaluation of asthma care in primary care practices.Apply for RFA HL 19 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Management of Asthma in Primary Care - Bioinformatics Center (U24 - Clinical Trial Required - Infrastructure)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838.
- This funding opportunity was created on 2018-08-02.
- Applicants must submit their applications by 2018-10-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the official title of this grant opportunity?
The opportunity is titled "Management of Asthma in Primary Care - Bioinformatics Center (U24 - Clinical Trial Required - Infrastructure)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA HL 19 006.
Which federal agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of award mechanism is used?
The award uses a cooperative agreement mechanism, indicating substantial involvement from NIH program staff and an emphasis on coordination, teamwork, and meeting program-wide milestones.
What activity code does this opportunity use?
This opportunity funds a Bioinformatics Center under the U24 activity code, which typically supports shared resources and infrastructure.
Is a clinical trial required under this FOA?
Yes. The FOA is labeled "Clinical Trial Required," and the expectation is that work will go beyond retrospective analyses to include prospective testing of management strategies consistent with NIH clinical trial definitions.
What is the main goal of the program?
The central aim is to strengthen evidence on how asthma is managed in real-world primary care by identifying what primary care providers currently do and then prospectively evaluating how effective those approaches are.
Does the program focus on a single asthma medication or a narrow intervention?
No. Rather than testing one medication or a narrow intervention, the project is structured to examine existing care practices and use findings to define "best practices" to guide future clinical decision-making in primary care settings.
Why are electronic health records (EHRs) central to this initiative?
EHR systems are the foundation for generating and testing care paradigms. Applicants are expected to leverage EHR data to understand patterns of asthma care, measure outcomes, and support the design and execution of prospective evaluations comparing different management approaches.
What is the role of the Bioinformatics Center in this program?
The Bioinformatics Center is responsible for the data and analytics side of the study, including building and maintaining analytical infrastructure, handling complex EHR-derived datasets, supporting data harmonization and quality control, developing analytic plans, and conducting statistical and informatics analyses to evaluate asthma management paradigms.
How does the Bioinformatics Center interact with other program components?
The Bioinformatics Center is expected to work closely with a separately funded Clinical Center, which has primary responsibility for study management, data collection operations, and the conduct of clinical trials.
What does "infrastructure" mean in the context of this U24 Bioinformatics Center?
In this context, "infrastructure" refers to the shared resources and capabilities needed to support EHR-based research and prospective evaluations, such as analytic platforms, data processing and harmonization workflows, quality control processes, and the statistical and informatics capacity to evaluate asthma care paradigms.
What kinds of analyses are expected from the Bioinformatics Center?
Based on the description, expected work includes informatics and statistical analyses using EHR-derived datasets, data harmonization across sources, data quality control, and analysis plans that support prospective testing and evaluation of asthma management approaches in primary care.
What is meant by evaluating asthma management "in real-world primary care"?
It means focusing on how asthma is actually managed in routine primary care practice settings, using real-world data from EHRs and generating practice-relevant evidence that can be integrated into primary care workflows.
What is the intended output or impact of the program?
The program intends to produce actionable, practice-relevant evidence about asthma management approaches that can improve consistency, quality, and outcomes for asthma patients in primary care, and help define best practices for future decision-making.
Is this opportunity considered discretionary funding?
Yes. The opportunity is categorized as discretionary funding.
What is the activity/category area for this opportunity?
It falls under the health activity category.
What is the CFDA number listed for this opportunity?
The CFDA number is 93.838.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories as listed); for-profit organizations other than small businesses; small businesses; and additional eligible entities as allowed by NIH policy.
Are any additional or special categories of applicants highlighted?
Yes. The FOA highlights "other eligible applicants" such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIS institutions, faith-based or community-based organizations, Hispanic-serving institutions, HBCUs, tribally controlled colleges and universities, regional organizations, and U.S. territories or possessions, indicating interest in broad participation across diverse communities and care settings.
Can non-U.S. (foreign) organizations apply?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization include a non-domestic component?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy definitions?
No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed for this opportunity.
Where must the project be carried out?
Based on the stated restrictions, the project must be carried out entirely within allowable U.S.-based organizational structures and locations, without foreign components.
What is the listed closing date for this opportunity?
The original closing date listed is October 31, 2018.
What is the creation date shown for the FOA record?
The FOA record shows a creation date of August 2, 2018.
Does the summary specify an award ceiling or the expected number of awards?
No. The provided summary fields do not specify an award ceiling or the expected number of awards.
How is the overall program structured?
The structure indicates a coordinated, multi-component program where the Bioinformatics Center plays a central enabling role for rigorous EHR-driven evaluation, while a separately funded Clinical Center leads study management, data collection operations, and clinical trial conduct, with NIH staff involved through the cooperative agreement mechanism.
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