Opportunity Information: Apply for RFA CA 19 061
This funding opportunity, RFA-CA-19-061, is a National Cancer Institute (NCI) announcement that supports revision applications to existing, currently funded NCI U01 cooperative agreement projects. The central idea is to help active U01 research teams expand the scope of their parent project or move it forward faster by bringing in cancer informatics methods, tools, or resources that were created with support from the NCI Informatics Technology for Cancer Research (ITCR) Program. In practical terms, it is aimed at teams that already have an NCI U01 award and want to strengthen or accelerate their ongoing cancer research by adopting, adapting, or integrating an ITCR-developed technology rather than building new informatics infrastructure from scratch.
The program is explicitly designed to spark new collaborations, especially interdisciplinary partnerships between groups focused on cancer research questions and groups or communities that have already developed informatics technologies through ITCR funding. The revisions are intended to encourage real-world uptake of these tools, push them into broader research use, and demonstrate that they can be effectively integrated into active cancer studies. The emphasis is on enabling cancer research and speeding scientific discovery by leveraging innovative informatics capabilities, whether that means improved data integration, analysis, sharing, workflow automation, or other technology-enabled advances that directly benefit the aims of the parent U01 study.
From an administrative standpoint, the award mechanism is a cooperative agreement (U01), which generally indicates substantial scientific and/or programmatic involvement by NIH/NCI staff compared with a standard grant. Clinical trials are listed as optional, meaning proposed work may involve a clinical trial if appropriate, but it does not have to. The activity area is categorized under Education and Health, and the listing falls under CFDA 93.396. The announcement was issued by the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), through NCI.
In terms of who can apply, eligibility is broad across many organization types, including state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside higher education); for-profit organizations other than small businesses; and small businesses. However, the key practical constraint is embedded in the purpose statement: the FOA is for revision applications from currently funded NCI U01 projects, so an applicant generally must already hold an eligible parent U01 award and be proposing a revision that meaningfully builds on that active project using ITCR-supported informatics resources.
The funding parameters are modest and targeted: the award ceiling is $100,000, with an expected total of about 4 awards. That size signals that the FOA is meant to fund focused add-on work, such as incorporating an ITCR tool into an existing study pipeline, extending the parent project with a new informatics-driven aim, validating an ITCR method in the context of the parent study, or making practical adaptations needed to deploy or scale a tool for the relevant research community. It is not structured as a large, multi-year standalone build; it is a supplement-style revision intended to add clear value to an existing U01 project.
Timing details in the source information show a creation date of July 31, 2019, with an original closing date of November 20, 2019. While those dates indicate the specific submission window for that cycle, the main takeaway for summarizing the opportunity is the intent: NCI wanted to accelerate progress in active U01 cancer research projects by incentivizing teams to incorporate proven ITCR-funded informatics technologies, thereby promoting broader adoption, stronger cross-team collaboration, and faster translation of informatics innovation into everyday cancer research practice.Apply for RFA CA 19 061
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on Jul 31, 2019.
- Applicants must submit their applications by Nov 20, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs) - RFA-CA-19-061 (NCI U01 Revision Applications Using ITCR Technologies)
1) What is RFA-CA-19-061?
RFA-CA-19-061 is a National Cancer Institute (NCI) funding opportunity that supports revision applications to existing, currently funded NCI U01 cooperative agreement projects. The revisions are meant to help active U01 teams expand the scope of their parent project or move it forward faster by incorporating cancer informatics methods, tools, or resources developed with support from the NCI Informatics Technology for Cancer Research (ITCR) Program.
2) What is the main purpose of this opportunity?
The purpose is to accelerate progress in active NCI-funded U01 cancer research projects by incentivizing teams to adopt, adapt, or integrate ITCR-developed informatics technologies rather than building new informatics infrastructure from scratch. The emphasis is on enabling cancer research and speeding scientific discovery through technology-enabled advances that directly strengthen the aims of the parent U01 study.
3) Who is the sponsoring agency?
The announcement is issued by the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), through the National Cancer Institute (NCI).
4) What kind of application is being requested (new project or revision)?
This opportunity is specifically for revision applications to existing, currently funded NCI U01 cooperative agreement projects. It is not described as a standalone, large, multi-year build; it is positioned as a targeted add-on revision intended to provide clear value to an already active U01 project.
5) What award mechanism is used?
The mechanism is a cooperative agreement (U01). In general, a cooperative agreement indicates substantial scientific and/or programmatic involvement by NIH/NCI staff compared with a standard grant mechanism.
6) Does my organization need to already have an NCI U01 award to apply?
In practical terms, yes. Although the eligibility list includes many organization types, the purpose statement makes a key constraint clear: this funding opportunity is for revision applications from currently funded NCI U01 projects. An applicant generally must already hold an eligible parent U01 award and propose a revision that meaningfully builds on that active project using ITCR-supported informatics resources.
7) What kinds of organizations are eligible to apply?
Eligibility is broad and includes: state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside higher education); for-profit organizations other than small businesses; and small businesses. However, the practical eligibility requirement is that the applicant must be able to submit a revision to a currently funded NCI U01 project.
8) What is ITCR and how does it relate to this opportunity?
ITCR refers to the NCI Informatics Technology for Cancer Research Program. This opportunity is designed to promote real-world uptake of informatics methods, tools, or resources created with ITCR support by integrating them into active U01 cancer research projects.
9) What types of work does the revision funding support?
The funding is intended for focused work that strengthens or accelerates the parent U01 through the use of ITCR-developed technology. Examples described include incorporating an ITCR tool into an existing study pipeline, extending the parent project with a new informatics-driven aim, validating an ITCR method in the context of the parent study, or making practical adaptations needed to deploy or scale a tool for the relevant research community.
10) Is the goal to build new informatics infrastructure from scratch?
No. The opportunity is aimed at helping active U01 teams strengthen or accelerate their ongoing research by adopting, adapting, or integrating an ITCR-developed technology rather than creating new informatics infrastructure from the ground up.
11) What kinds of informatics improvements are emphasized?
The emphasis is on informatics capabilities that directly benefit the aims of the parent U01 study, including (as described) improved data integration, analysis, sharing, workflow automation, or other technology-enabled advances that help enable cancer research and speed scientific discovery.
12) Is collaboration encouraged?
Yes. The program is explicitly designed to spark new collaborations, particularly interdisciplinary partnerships between teams focused on cancer research questions and groups or communities that have already developed informatics technologies through ITCR funding.
13) How many awards are expected and what is the maximum award size?
The award ceiling is $100,000, and the expected number of awards is about 4. This indicates the FOA is meant to fund targeted, add-on revision work rather than large-scale projects.
14) Are clinical trials required?
No. Clinical trials are listed as optional. Proposed work may involve a clinical trial if appropriate, but a clinical trial is not required.
15) What is the CFDA number associated with this opportunity?
The listing falls under CFDA 93.396.
16) What is the activity area or general topic category?
The activity area is categorized under Education and Health, and the scientific focus is on accelerating cancer research by leveraging ITCR-supported informatics technologies within active NCI U01 projects.
17) What is the timeline information provided for this funding opportunity?
The source information lists a creation date of July 31, 2019, with an original closing date of November 20, 2019. These dates reflect the specific submission window for that cycle as provided.
18) What is the overall intended impact of the revisions supported by this FOA?
The intended impact is to speed progress in ongoing U01 cancer studies by integrating proven ITCR-funded informatics technologies, promoting broader adoption of these tools, strengthening cross-team collaboration, and accelerating the translation of informatics innovation into everyday cancer research practice.
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