Opportunity Information: Apply for RFA CA 19 061

This funding opportunity, RFA-CA-19-061, is a National Cancer Institute (NCI) announcement that supports revision applications to existing, currently funded NCI U01 cooperative agreement projects. The central idea is to help active U01 research teams expand the scope of their parent project or move it forward faster by bringing in cancer informatics methods, tools, or resources that were created with support from the NCI Informatics Technology for Cancer Research (ITCR) Program. In practical terms, it is aimed at teams that already have an NCI U01 award and want to strengthen or accelerate their ongoing cancer research by adopting, adapting, or integrating an ITCR-developed technology rather than building new informatics infrastructure from scratch.

The program is explicitly designed to spark new collaborations, especially interdisciplinary partnerships between groups focused on cancer research questions and groups or communities that have already developed informatics technologies through ITCR funding. The revisions are intended to encourage real-world uptake of these tools, push them into broader research use, and demonstrate that they can be effectively integrated into active cancer studies. The emphasis is on enabling cancer research and speeding scientific discovery by leveraging innovative informatics capabilities, whether that means improved data integration, analysis, sharing, workflow automation, or other technology-enabled advances that directly benefit the aims of the parent U01 study.

From an administrative standpoint, the award mechanism is a cooperative agreement (U01), which generally indicates substantial scientific and/or programmatic involvement by NIH/NCI staff compared with a standard grant. Clinical trials are listed as optional, meaning proposed work may involve a clinical trial if appropriate, but it does not have to. The activity area is categorized under Education and Health, and the listing falls under CFDA 93.396. The announcement was issued by the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), through NCI.

In terms of who can apply, eligibility is broad across many organization types, including state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside higher education); for-profit organizations other than small businesses; and small businesses. However, the key practical constraint is embedded in the purpose statement: the FOA is for revision applications from currently funded NCI U01 projects, so an applicant generally must already hold an eligible parent U01 award and be proposing a revision that meaningfully builds on that active project using ITCR-supported informatics resources.

The funding parameters are modest and targeted: the award ceiling is $100,000, with an expected total of about 4 awards. That size signals that the FOA is meant to fund focused add-on work, such as incorporating an ITCR tool into an existing study pipeline, extending the parent project with a new informatics-driven aim, validating an ITCR method in the context of the parent study, or making practical adaptations needed to deploy or scale a tool for the relevant research community. It is not structured as a large, multi-year standalone build; it is a supplement-style revision intended to add clear value to an existing U01 project.

Timing details in the source information show a creation date of July 31, 2019, with an original closing date of November 20, 2019. While those dates indicate the specific submission window for that cycle, the main takeaway for summarizing the opportunity is the intent: NCI wanted to accelerate progress in active U01 cancer research projects by incentivizing teams to incorporate proven ITCR-funded informatics technologies, thereby promoting broader adoption, stronger cross-team collaboration, and faster translation of informatics innovation into everyday cancer research practice.

  • The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
  • This funding opportunity was created on Jul 31, 2019.
  • Applicants must submit their applications by Nov 20, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $100,000.00 in funding.
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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