Opportunity Information: Apply for RFA AI 19 010
The grant opportunity titled "Limited Competition: Nonhuman Primate (NHP) Radiation Survivor Cohort (RSC) (U01 Clinical Trial Not Allowed)" is a National Institutes of Health cooperative agreement designed to maintain and scientifically leverage a rare, long-term cohort of nonhuman primates that have survived radiation exposure. The central goal is to ensure continued preservation and high-quality veterinary and husbandry care for these animals while also enabling specialized research that tracks and addresses the long-term, or "late," health effects that can emerge after radiation exposure. Because nonhuman primates often show radiation responses that are closer to humans than many other animal models, the cohort is treated as a uniquely valuable resource for understanding how radiation injuries evolve over time, from early damage through delayed disease development, and for evaluating possible medical monitoring strategies, treatments, and interventions.
This is a limited competition FOA, meaning eligibility is restricted rather than open to all applicant types. The eligible applicants listed are public and state-controlled institutions of higher education, reflecting the expectation that the awardee will have substantial existing infrastructure, specialized expertise, and regulatory capacity to support complex animal care and longitudinal research programs. The funding mechanism is a U01 cooperative agreement, which typically indicates a more hands-on partnership with the NIH compared to a standard research project grant. In practical terms, that usually means the funded institution should expect meaningful scientific and programmatic involvement from the sponsoring NIH component in areas such as oversight, coordination, milestones, data/resource sharing expectations, and alignment with broader government-supported radiation research priorities. The FOA also clearly states "Clinical Trial Not Allowed," signaling that the supported work is not intended to be structured as a human clinical trial and reinforcing that the focus is on animal cohort care and related non-clinical research activities.
A defining requirement of this opportunity is the capacity to house, care for, and medically monitor a combined minimum of 120 animals, including both irradiated primates and unirradiated controls. The cohort is described as having animals exposed at various ages, which is important scientifically because age at exposure can strongly influence later outcomes such as organ injury, immune changes, cancer risk, and other chronic conditions. Beyond maintaining the existing colony, the successful applicant must also be able to accept additional radiation-exposed animals transferred from other government-supported studies. That requirement implies the awardee needs flexible housing and quarantine capabilities, robust veterinary screening and integration procedures, and the staffing depth to expand cohort management without compromising welfare or data quality. It also suggests the program is meant to serve as a national, consolidating resource so that animals from multiple studies can be followed long-term rather than being lost to follow-up after the original experimental endpoints.
From a research standpoint, the supported activities emphasize continuous observation and treatment as the animals age, with the intent of building a clearer picture of the natural history of radiation exposure. "Natural history" here refers to the progression of biological effects over time, including both early injuries (those appearing soon after exposure) and late effects that may take months to years to manifest. The FOA highlights medical monitoring, study, treatment, and intervention related to late effects, indicating that the program is not only observational but is also expected to support targeted scientific investigations and medically relevant management approaches within the cohort. The long-term nature of the cohort is a major scientific advantage because it allows repeated measurements, longitudinal biospecimen collection, and the ability to link early biomarkers or clinical findings to later disease outcomes in a way that short-term studies cannot.
Administratively, this opportunity is listed under the Department of Health and Human Services within NIH, with a health-related activity category and CFDA number 93.855. The opportunity number is RFA AI 19 010, it was created on February 25, 2019, and had an original closing date of May 31, 2019. The expected number of awards is one, which aligns with the idea that the government intends to designate a single primary site to serve as the steward of this specialized cohort and the associated long-term program. The award ceiling is listed as 0, which commonly indicates that a strict upper cap is not specified in the public synopsis and that the budget is likely to be determined based on justified needs, scope, and available funds rather than a simple published maximum.
Overall, the opportunity is essentially a combination of colony stewardship and strategic research enablement: it funds an institution capable of delivering high-standard long-term care and monitoring for a large radiation survivor cohort of nonhuman primates, while also conducting and supporting specialized studies that clarify how radiation injuries unfold over time and how late effects might be prevented, detected earlier, or treated. The emphasis on maintaining both irradiated animals and matched controls, accommodating animals from other federal efforts, and running the program under a cooperative agreement structure reflects a broader national interest in preserving an irreplaceable research asset and extracting long-term, medically relevant insights from it.Apply for RFA AI 19 010
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Nonhuman Primate (NHP) Radiation Survivor Cohort (RSC) (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on Feb 25, 2019.
- Applicants must submit their applications by May 31, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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